Endocannabinoids and myelin


  • Endocannabinoids

  • Astrocytes

  • Oligodendrocytes

  • Microglia


  • Immunohistochemistry

  • Flow cytometry

  • Electrophysiology

  • Calcium Imaging

  • human iPSCs

Role of neuroglial endocannabinoid system during myelination and myelin pathology

We study the endocannabinoid system as regulator of glial cell function with regard to the biology and pathology of the myelin sheath. A main objective of our research activity is to understand the role of cannabinoid CB1 receptors located in astrocytes and oligodendrocyte populations during white matter damage/repair and decipher their utility as possible therapeutic targets in multiple sclerosis. We use experimental in vitro and in vivo rodent models as well as hiPSC technology.

Funded by ISCIII, ARSEP foundation and Basque Government

Calcium imaging by confocal microscopy

Publications related to this topic

  • Bernal-Chico A, Tepavcevic V, Manterola A, Utrilla C, Matute C, Mato S. Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells. Glia 2022; Mar 30. [LINK]

  • Bernal-Chico A, Canedo M, Manterola A, Victoria Sánchez-Gómez M, Pérez-Samartín A, Rodríguez-Puertas R, Matute C, Mato S. Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo. Glia 2015; 63: 163–176. [LINK]

  • Moreno-García A, Bernal-Chico A, Colomer T, Rodríguez-Antigüedad A, Matute C, Mato S. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination. Biomolecules 2020; 10. [LINK]

  • Manterola A, Bernal-Chico A, Cipriani R, Ruiz A, Pérez-Samartín A, Moreno-Rodríguez M, Hsu K-L, Cravatt BF, Brown JM, Rodríguez-Puertas R, Matute C, Mato S. Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis. Neuropharmacology 2018; 141: 181–191. [LINK]

  • Manterola A, Bernal-Chico A, Cipriani R, Canedo-Antelo M, Moreno-García Á, Martín-Fontecha M, Pérez-Cerdá F, Sánchez-Gómez MV, Ortega-Gutiérrez S, Brown JM, Hsu K-L, Cravatt B, Matute C, Mato S. Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination. Biochem Pharmacol 2018; 157: 189–201. [LINK]